It can be very tempting to just leave everything as it is after you're done setting up different products to promote in your autoresponder series. The truth is that some offers may not convert as well as you thought they would. You need to check your stats and periodically clean things out. Test different offers to make sure the needs of your subscribers are being met — and that you're earning as much money as possible.
That may mean trying different affiliate offers or taking note of your subscribers' feedback and creating products based around that. Even though your autoresponder series can be “set and forget,” that's not always the best case scenario.